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After some heavyweight clashes in week 11 of the NFL season, week 12 throws up some more lopsided affairs, which could be a great help to fantasy football players.
Josh Allen led the way in week 11 with his stellar performance against the Tampa Bay Buccaneers as the Buffalo Bills romped to a 44-32 win at Highmark Stadium, with the 29-year-old cancelling out two interceptions with six total touchdowns.
The next best fantasy performer was San Francisco 49ers running back Christian McCaffrey, who totalled 121 yards from scrimmage and three touchdowns, including one receiving touchdown, with the 29-year-old running back becoming a beneficiary of Brock Purdy’s return to the lineup.
Perhaps the surprise performer of the week was Buccaneers running back Sean Tucker, whose three total touchdowns totalled almost 75 per cent of all of Tampa’s points in their loss at Buffalo.
The other two top performers in last week’s top five were Michael Wilson of the Arizona Cardinals, who tallied a monster 185 receiving yards off 15 receptions, and Carolina Panthers pass catcher Tetairoa McMillan, who caught two touchdowns and totalled 130 yards off eight receptions.
Before we get into the picks, if you would like to get involved with the UK’s dedicated NFL fantasy app, download the Fantasy Gameday app today and use the code FULL10 when you sign up to get a free £7.50 game entry, and always gamble responsibly.
Captain – Jahmyr Gibbs, Detroit Lions vs New York Giants, 9000
Jahmyr Gibbs comes in as the third most expensive running back this week, at 9,000, behind only McCaffrey (9600) and Jonathan Taylor (9400), and with Gibbs facing off against the worst rushing defence in the NFL – the New York Giants – it feels like Gibbs will have a big day.
In a season where running backs are lighting up the league, Gibbs is among the leading pack in fantasy football terms, coming into week 12 as the fourth-best fantasy running back.
Last week, when @HaydenWinks called Jahmyr Gibbs a top-12 RB, everyone hated it.
— Underdog Fantasy – Josh & Hayden (@UDFootballShow) November 20, 2025
He finished RB12.
This week? We’ve got Gibbs as our RB1. Let’s dance. pic.twitter.com/y28VAwZ5bd
With the Lions looking to bounce back from their disappointing defeat in Philadelphia on Sunday Night Football, Gibbs will be hoping to put up similar numbers to the 19.6 fantasy points he put up against the Eagles.
The 23-year-old had 12 carries for 39 yards and five receptions for 107 yards off eight targets without finding the endzone, something that seems highly likely against the porous Giants.
Quarterback – Jared Goff, Detroit Lions vs New York Giants, 7200
My ideal pick for the quarterback pick, if you’re a regular fantasy owner, would be Bryce Young for the Carolina Panthers, but Fantasy Gameday picks only count for Sunday’s 6 pm and 9:05/25 pm slates, hence Jared Goff getting the nod here.
The New York Giants give up the second-most points to quarterbacks in fantasy behind only the Dallas Cowboys, and Goff has shown he can put up big numbers against bad defences.
In week 10, Goff tallied three touchdowns and 320 yards against the Washington Commanders’ defence (who rank third in the list behind the Giants), and owners of the 31-year-old will hope he can put up a similar showing against a leaky Giants group.
Running Back – TreVeyon Henderson, New England Patriots @ Cincinnati Bengals, 6200
TreVeyon Henderson is the tied-13th most expensive running back in the game, which looks like a true bargain heading into the New England Patriots’ week 12 matchup.
The Patriots will travel southwest to Cincinnati to take on the Bengals, and this AFC matchup is huge for Henderson owners in fantasy.
The Cincinnati Bengals are allowing 34.09 fantasy ppg to RBs this season, the most in the NFL.
— NFL Fantasy Football (@NFLFantasy) November 18, 2025
Will TreVeyon Henderson keep up the hot streak this week? pic.twitter.com/pzzStTt8Qg
The Bengals give up the most fantasy points to opposing running backs of any team in the league, and the rookie from Ohio State will look to make an impact back in the state where he made his name at the college level.
Henderson is coming off a monster game against the New York Jets on Thursday Night Football in week 11, with the 23-year-old totalling three touchdowns and 93 total yards, scoring 32.3 fantasy points in the process.
Things look set to get a lot better for Henderson heading into week 12 off the back of that performance, as the Bengals’ run defence looks set to gift the former Ohio State back a huge day on Sunday.
Wide Receiver – AJ Brown, Philadelphia Eagles @ Dallas Cowboys, 5600
After a slow start to the 2025 NFL season, AJ Brown has come into his own in recent weeks, with the Philadelphia Eagles improving after the trade deadline.
In week 11, Brown only scored 11.9 fantasy points on a tough evening for the Eagles against a strong Lions defensive unit, but coming into their matchup against NFC East rivals, the Dallas Cowboys, Brown could be set for a bigger day.
Against the Lions, Brown led the team in receiving, totalling 49 yards from seven receptions, and with the Cowboys giving up the most points to opposition wide receivers in fantasy this year, it feels like a no-brainer to bet on that trend continuing.
Tight End – Hunter Henry, New England Patriots @ Cincinnati Bengals, 3400
It feels like a cheap shot to continually pick on the Bengals’ defence, but when they’re coming up against such a good offence and their numbers this season have been so poor, it’s difficult not to keep picking Patriots.
Hunter Henry ranks as the 13th-best tight end in fantasy this season, and his price reflects that, but the Bengals have given up the most points to tight ends in the NFL this season, and that fact is hard to ignore when looking at setting your lineup this Sunday.
Not only do they give up the most, but the Bengals have given up 37 more points than the next closest team so far this season, a stat Henry will love to see.
Henry is a big part of the offence that Drake Maye has led so well this season, and if the numbers are to be believed, it seems likely that connection will continue in Cincinnati in week 12.
Fantasy Football picks summary
This week, the picks are:
- Captain – Jahymr Gibbs
- QB – Jared Goff
- RB – TreVeyon Henderson
- WR – AJ Brown
- TE – Hunter Henry
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